KEGG   NETWORK: N00145Help
Entry
N00145                      Network                                

Name
Extrinsic apoptotic pathway
Definition
TNF -> TNFRSF1A -> TRADD -- FADD -> CASP8 -> (CASP3,CASP7)
  Expanded
7124 -> 7132 -> 8717 -- 8772 -> 841 -> (836,840)
Type
Reference
Pathway
hsa04210  Apoptosis
Gene
7124  TNF; tumor necrosis factor
7132  TNFRSF1A; TNF receptor superfamily member 1A
8717  TRADD; TNFRSF1A associated via death domain
8772  FADD; Fas associated via death domain
841  CASP8; caspase 8
836  CASP3; caspase 3
840  CASP7; caspase 7
Reference
  Authors
Vucic D, Dixit VM, Wertz IE
  Title
Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.
  Journal
Nat Rev Mol Cell Biol 12:439-52 (2011)
DOI:10.1038/nrm3143
Reference
  Authors
Beesoo R, Neergheen-Bhujun V, Bhagooli R, Bahorun T
  Title
Apoptosis inducing lead compounds isolated from marine organisms of potential relevance in cancer treatment.
  Journal
Mutat Res 768:84-97 (2014)
DOI:10.1016/j.mrfmmm.2014.03.005
Reference
  Authors
MacFarlane M, Williams AC
  Title
Apoptosis and disease: a life or death decision.
  Journal
EMBO Rep 5:674-8 (2004)
DOI:10.1038/sj.embor.7400191

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