KEGG   NETWORK: N00157
Entry
N00157                      Network                                
Name
KSHV vGPCR to GNB/G-ERK signaling pathway
Definition
vGPCR -> GNB/G
  Expanded
K21667 -> (2782,2783,2784,59345,10681,54331,2785,2786,2787,2788,94235,2790,2791,55970,51764,2792,2793)
Class
nt06533 Chemokine signaling
nt06224 CXCR signaling (cancer)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
2782  GNB1; G protein subunit beta 1
2783  GNB2; G protein subunit beta 2
2784  GNB3; G protein subunit beta 3
59345  GNB4; G protein subunit beta 4
10681  GNB5; G protein subunit beta 5
54331  GNG2; G protein subunit gamma 2
2785  GNG3; G protein subunit gamma 3
2786  GNG4; G protein subunit gamma 4
2787  GNG5; G protein subunit gamma 5
2788  GNG7; G protein subunit gamma 7
94235  GNG8; G protein subunit gamma 8
2790  GNG10; G protein subunit gamma 10
2791  GNG11; G protein subunit gamma 11
55970  GNG12; G protein subunit gamma 12
51764  GNG13; G protein subunit gamma 13
2792  GNGT1; G protein subunit gamma transducin 1
2793  GNGT2; G protein subunit gamma transducin 2
Perturbant
K21667 (vGPCR)  vGPCR; KSHV G-protein coupled receptor
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
  Journal
Cancer Res 60:4873-80 (2000)
Reference
PMID:27518127
  Authors
Abere B, Schulz TF
  Title
KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
  Journal
Curr Opin Virol 20:11-19 (2016)
DOI:10.1016/j.coviro.2016.07.008
Reference
PMID:15573137
  Authors
Sodhi A, Montaner S, Gutkind JS
  Title
Viral hijacking of G-protein-coupled-receptor signalling networks.
  Journal
Nat Rev Mol Cell Biol 5:998-1012 (2004)
DOI:10.1038/nrm1529

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (17)   
Literature (4)   
   PubMed (4)   
All databases (23)   

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