KEGG   NETWORK: N00166Help
Entry
N00166                      Network                                

Name
KSHV vFLIP to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
kshvFLIP -| CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K21662 -| 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06231 Apoptosis
nt06131 Apoptosis (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Perturbant
K21662  vFLIP, K13, ORF71; KSHV FLICE inhibitory protein
Reference
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025

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