KEGG   NETWORK: N00174
Entry
N00174                      Network                                

Name
KSHV vFLIP to TNF-NFKB signaling pathway
Definition
vFLIP -> TRAF2 -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB
  Expanded
K21662 -> 7186 -> ((10454,23118,257397)+6885) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06223 TNF signaling
nt06123 TNF signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
7186  TRAF2; TNF receptor associated factor 2
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K21662 (vFLIP)  vFLIP; KSHV FLICE inhibitory protein
Reference
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0

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