KEGG   NETWORK: N00175
Entry
N00175                      Network                                

Name
KSHV LANA to Wnt signaling pathway
Definition
LANA -| GSK3B -| CTNNB1 -> TCF/LEF => CCND1
  Expanded
K21664 -| 2932 -| 1499 -> (6932,83439,6934,51176) => 595
Class
nt06215 WNT signaling
nt06115 WNT signaling (viruses and bacteria)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Pathogen
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00041  Kaposi sarcoma
Gene
2932  GSK3B; glycogen synthase kinase 3 beta
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
595  CCND1; cyclin D1
Perturbant
K21664 (LANA)  vLANA; KSHV latency-associated nuclear antigen
Reference
  Authors
Fujimuro M, Wu FY, ApRhys C, Kajumbula H, Young DB, Hayward GS, Hayward SD
  Title
A novel viral mechanism for dysregulation of beta-catenin in Kaposi's sarcoma-associated herpesvirus latency.
  Journal
Nat Med 9:300-6 (2003)
DOI:10.1038/nm829
Reference
  Authors
Fujimuro M, Hayward SD
  Title
Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
  Journal
J Mol Med (Berl) 82:223-31 (2004)
DOI:10.1007/s00109-003-0519-7
Reference
  Authors
Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
  Journal
Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Reference
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (7)   
   KEGG GENES (7)   
Literature (4)   
   PubMed (4)   
All databases (13)   

Download RDF
DBGET integrated database retrieval system