KEGG   NETWORK: N00182Help
Entry
N00182                      Network                                

Name
IGF-IGFR-PI3K-NFKB signaling pathway
Definition
IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
  Expanded
3479 -> 3480 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06214 PI3K signaling
nt06114 PI3K signaling (viruses)
nt06164 Kaposi sarcoma-associated herpesvirus (KSHV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
3479  IGF1; insulin like growth factor 1
3480  IGF1R; insulin like growth factor 1 receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Salminen A, Kaarniranta K
  Title
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling.
  Journal
Cell Signal 22:573-7 (2010)
DOI:10.1016/j.cellsig.2009.10.006
Reference
  Authors
Jimenez Del Rio M, Velez-Pardo C
  Title
Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway.
  Journal
Growth Factors 24:67-78 (2006)
DOI:10.1080/08977190500361788
Reference
  Authors
Bai D, Ueno L, Vogt PK
  Title
Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt.
  Journal
Int J Cancer 125:2863-70 (2009)
DOI:10.1002/ijc.24748

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