KEGG   NETWORK: N00215Help
Entry
N00215                      Network                                

Name
KITLG-KIT-RAS-ERK signaling pathway
Definition
KITLG -> KIT -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
4254 -> 3815 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06275 Acute myeloid leukemia
Type
Reference
Pathway
hsa04014  Ras signaling pathway
Gene
4254  KITLG; KIT ligand
3815  KIT; KIT proto-oncogene receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Mithraprabhu S, Loveland KL
  Title
Control of KIT signalling in male germ cells: what can we learn from other systems?
  Journal
Reproduction 138:743-57 (2009)
DOI:10.1530/REP-08-0537
Reference
  Authors
Draber P, Halova I, Polakovicova I, Kawakami T
  Title
Signal transduction and chemotaxis in mast cells.
  Journal
Eur J Pharmacol 778:11-23 (2016)
DOI:10.1016/j.ejphar.2015.02.057
Reference
  Authors
Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y, Sugiyama H
  Title
The C-kit receptor-mediated signal transduction and tumor-related diseases.
  Journal
Int J Biol Sci 9:435-43 (2013)
DOI:10.7150/ijbs.6087

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