KEGG   NETWORK: N00217Help
Entry
N00217                      Network                                

Name
FLT3LG-FLT3-RAS-ERK signaling pathway
Definition
FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
2323 -> 2322 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06275 Acute myeloid leukemia
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
2323  FLT3LG; fms related tyrosine kinase 3 ligand
2322  FLT3; fms related tyrosine kinase 3
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Grafone T, Palmisano M, Nicci C, Storti S
  Title
An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: biology and treatment.
  Journal
Oncol Rev 6:e8 (2012)
DOI:10.4081/oncol.2012.e8
Reference
  Authors
Stirewalt DL, Radich JP.
  Title
The role of FLT3 in haematopoietic malignancies.
  Journal
Nat Rev Cancer 3:650-65 (2003)
DOI:10.1038/nrc1169
Reference
  Authors
Gocek E, Studzinski GP
  Title
The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy.
  Journal
J Clin Med 4:504-34 (2015)
DOI:10.3390/jcm4040504
Reference
  Authors
Weisberg E, Barrett R, Liu Q, Stone R, Gray N, Griffin JD
  Title
FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.
  Journal
Drug Resist Updat 12:81-9 (2009)
DOI:10.1016/j.drup.2009.04.001

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