KEGG   NETWORK: N00219Help
Entry
N00219                      Network                                

Name
FLT3LG-FLT3-STAT5 signaling pathway
Definition
FLT3LG -> FLT3 -> STAT5
  Expanded
2323 -> 2322 -> (6776,6777)
Class
nt06219 JAK-STAT signaling
nt06275 Acute myeloid leukemia
Type
Reference
Gene
2323  FLT3LG; fms related tyrosine kinase 3 ligand
2322  FLT3; fms related tyrosine kinase 3
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
Reference
  Authors
Zhang S, Fukuda S, Lee Y, Hangoc G, Cooper S, Spolski R, Leonard WJ, Broxmeyer HE
  Title
Essential role of signal transducer and activator of transcription (Stat)5a but not Stat5b for Flt3-dependent signaling.
  Journal
J Exp Med 192:719-28 (2000)
DOI:10.1084/jem.192.5.719
Reference
  Authors
Swords R, Freeman C, Giles F
  Title
Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia.
  Journal
Leukemia 26:2176-85 (2012)
DOI:10.1038/leu.2012.114

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