KEGG   NETWORK: N00220Help
Entry
N00220                      Network                                

Name
PTEN-PIP3-AKT signaling pathway
Definition
PTEN -| PIP3 -> AKT
  Expanded
5728 -| C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
nt06263 Hepatocellular carcinoma
nt06267 Small cell lung cancer
nt06268 Melanoma
nt06270 Breast cancer
nt06271 Endometrial cancer
nt06272 Prostate cancer
nt06273 Glioma
nt06114 PI3K signaling (viruses)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
5728  PTEN; phosphatase and tensin homolog
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
  Authors
Song MS, Salmena L, Pandolfi PP
  Title
The functions and regulation of the PTEN tumour suppressor.
  Journal
Nat Rev Mol Cell Biol 13:283-96 (2012)
DOI:10.1038/nrm3330
Reference
  Authors
Hollander MC, Blumenthal GM, Dennis PA
  Title
PTEN loss in the continuum of common cancers, rare syndromes and mouse models.
  Journal
Nat Rev Cancer 11:289-301 (2011)
DOI:10.1038/nrc3037
Reference
  Authors
Lasarge CL, Danzer SC
  Title
Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation.
  Journal
Front Mol Neurosci 7:18 (2014)
DOI:10.3389/fnmol.2014.00018

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