KEGG   NETWORK: N00226
Entry
N00226                      Network                                

Name
EBV EBNA3A/3B/3C to RBP-Jk-mediated transcription
Definition
(EBNA3A,EBNA3B,EBNA3C) -| RBPJ => LMP1
  Expanded
(K21855,K21856,K19458) -| 3516 => K19459
Class
nt06140 Transcription (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
3516  RBPJ; recombination signal binding protein for immunoglobulin kappa J region
Perturbant
K21855 (EBNA3A)  EBNA3; EBV nuclear antigen 3
K21856 (EBNA3B)  EBNA4; EBV nuclear antigen 4
K19458 (EBNA3C)  EBNA6; EBV nuclear antigen 6
K19459 (LMP1)  LMP1; EBV latent membrane protein 1
Reference
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
  Authors
Maruo S, Johannsen E, Illanes D, Cooper A, Zhao B, Kieff E
  Title
Epstein-Barr virus nuclear protein 3A domains essential for growth of lymphoblasts: transcriptional regulation through RBP-Jkappa/CBF1 is critical.
  Journal
J Virol 79:10171-9 (2005)
DOI:10.1128/JVI.79.16.10171-10179.2005
Reference
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046

DBGET integrated database retrieval system