KEGG   NETWORK: N00231Help
Entry
N00231                      Network                                

Name
TGFA-EGFR-PI3K signaling pathway
Definition
TGFA -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
7039 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06214 PI3K signaling
nt06260 Colorectal cancer
nt06263 Hepatocellular carcinoma
Type
Reference
Pathway
hsa04012  ErbB signaling pathway
hsa04151  PI3K-Akt signaling pathway
Gene
7039  TGFA; transforming growth factor alpha
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Janku F, Stewart DJ, Kurzrock R
  Title
Targeted therapy in non-small-cell lung cancer--is it becoming a reality?
  Journal
Nat Rev Clin Oncol 7:401-14 (2010)
DOI:10.1038/nrclinonc.2010.64
Reference
  Authors
Mascia F, Denning M, Kopan R, Yuspa SH
  Title
The black box illuminated: signals and signaling.
  Journal
J Invest Dermatol 132:811-9 (2012)
DOI:10.1038/jid.2011.406
Reference
  Authors
Marmor MD, Skaria KB, Yarden Y.
  Title
Signal transduction and oncogenesis by ErbB/HER receptors.
  Journal
Int J Radiat Oncol Biol Phys 58:903-13 (2004)
DOI:10.1016/j.ijrobp.2003.06.002
Reference
  Authors
Scaltriti M, Baselga J.
  Title
The epidermal growth factor receptor pathway: a model for targeted therapy.
  Journal
Clin Cancer Res 12:5268-72 (2006)
DOI:10.1158/1078-0432.CCR-05-1554

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