KEGG   NETWORK: N00241Help
Entry
N00241                      Network                                

Name
TGFBR2-reduced expression to TGF-beta signaling pathway
Definition
(TGFBR2*+TGFBR1) // (SMAD2,SMAD3)
  Expanded
(7048v2+7046) // (4087,4088)
Class
nt06218 TGFB signaling
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
7048  TGFBR2; transforming growth factor beta receptor 2
7046  TGFBR1; transforming growth factor beta receptor 1
4087  SMAD2; SMAD family member 2
4088  SMAD3; SMAD family member 3
Variant
7048v2  TGFBR2 reduced expression
Reference
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
  Authors
Achyut BR, Yang L
  Title
Transforming growth factor-beta in the gastrointestinal and hepatic tumor microenvironment.
  Journal
Gastroenterology 141:1167-78 (2011)
DOI:10.1053/j.gastro.2011.07.048
Reference
  Authors
Musch A, Rabe C, Paik MD, Berna MJ, Schmitz V, Hoffmann P, Nischalke HD, Sauerbruch T, Caselmann WH
  Title
Altered expression of TGF-beta receptors in hepatocellular carcinoma--effects of a constitutively active TGF-beta type I receptor mutant.
  Journal
Digestion 71:78-91 (2005)
DOI:10.1159/000084523

DBGET integrated database retrieval system