KEGG   NETWORK: N00246Help
Entry
N00246                      Network                                

Name
HGF-overexpression to RAS-ERK signaling pathway
Definition
HGF* -> MET -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
3082v1 -> 4233 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06263 Hepatocellular carcinoma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
3082  HGF; hepatocyte growth factor
4233  MET; MET proto-oncogene, receptor tyrosine kinase
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
3082v1  HGF overexpression
Reference
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
  Authors
Harding JJ, Abou-Alfa GK
  Title
Systemic therapy for hepatocellular carcinoma.
  Journal
Chin Clin Oncol 2:37 (2013)
DOI:10.3978/j.issn.2304-3865.2013.07.06
Reference
  Authors
Lee D, Sung ES, Ahn JH, An S, Huh J, You WK
  Title
Development of antibody-based c-Met inhibitors for targeted cancer therapy.
  Journal
Immunotargets Ther 4:35-44 (2015)
DOI:10.2147/ITT.S37409

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