KEGG   NETWORK: N00274
Entry
N00274                      Network                                

Name
HCV NS5A to RAS-ERK signaling pathway
Definition
NS5A -| GRB2
  Expanded
K22275 -| 2885
Class
nt06210 ERK signaling
nt06263 Hepatocellular carcinoma
nt06110 MAPK signaling (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
2885  GRB2; growth factor receptor bound protein 2
Perturbant
K22275 (NS5A)  NS5A; HCV non-structural protein 5A
Reference
  Authors
Tan SL, Nakao H, He Y, Vijaysri S, Neddermann P, Jacobs BL, Mayer BJ, Katze MG
  Title
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.
  Journal
Proc Natl Acad Sci U S A 96:5533-8 (1999)
DOI:10.1073/pnas.96.10.5533
Reference
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0

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