KEGG   NETWORK: N00317Help
Entry
N00317                      Network                                

Name
AhR signaling pathway
Definition
TCDD -> AHR -- ARNT => (CDKN1A,CDKN1B,CYP1A1)
  Expanded
C07557 -> 196 -- 405 => (1026,1027,1543)
Class
nt06360 Cushing syndrome
Type
Reference
Gene
196  AHR; aryl hydrocarbon receptor
405  ARNT; aryl hydrocarbon receptor nuclear translocator
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1027  CDKN1B; cyclin dependent kinase inhibitor 1B
1543  CYP1A1; cytochrome P450 family 1 subfamily A member 1
Metabolite
C07557  2,3,7,8-Tetrachlorodibenzodioxin
Reference
  Authors
Zhou L
  Title
AHR Function in Lymphocytes: Emerging Concepts.
  Journal
Trends Immunol 37:17-31 (2016)
DOI:10.1016/j.it.2015.11.007
Reference
  Authors
Bhattacharya S, Shoda LK, Zhang Q, Woods CG, Howell BA, Siler SQ, Woodhead JL, Yang Y, McMullen P, Watkins PB, Andersen ME
  Title
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches.
  Journal
Front Physiol 3:462 (2012)
DOI:10.3389/fphys.2012.00462
Reference
  Authors
Dworakowska D, Korbonits M, Aylwin S, McGregor A, Grossman AB
  Title
The pathology of pituitary adenomas from a clinical perspective.
  Journal
Front Biosci (Schol Ed) 3:105-16 (2011)
DOI:10.2741/136
Reference
  Authors
Lecoq AL, Kamenicky P, Guiochon-Mantel A, Chanson P
  Title
Genetic mutations in sporadic pituitary adenomas--what to screen for?
  Journal
Nat Rev Endocrinol 11:43-54 (2015)
DOI:10.1038/nrendo.2014.181

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