KEGG   NETWORK: N00324Help
Entry
N00324                      Network                                

Name
CRHR-PKA-ACTH signaling pathway
Definition
CRH -> CRHR -> GNAS -> ADCY -> cAMP -> PKA -> CREB -> ACTH
  Expanded
1392 -> (1394,1395) -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) -> 5443
Class
nt06310 CRH-ACTH-cortisol signaling
nt06360 Cushing syndrome
Type
Reference
Gene
1392  CRH; corticotropin releasing hormone
1394  CRHR1; corticotropin releasing hormone receptor 1
1395  CRHR2; corticotropin releasing hormone receptor 2
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
5443  POMC; proopiomelanocortin
Metabolite
C00575  3',5'-Cyclic AMP
Reference
  Authors
Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E
  Title
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
  Journal
Mol Endocrinol 16:1638-51 (2002)
DOI:10.1210/mend.16.7.0863
Reference
  Authors
Subbannayya T, Balakrishnan L, Sudarshan G, Advani J, Kumar S, Mahmood R, Nair B, Sirdeshmukh R, Mukherjee KK, Umathe SN, Raju R, Prasad TS
  Title
An integrated map of corticotropin-releasing hormone signaling pathway.
  Journal
J Cell Commun Signal 7:295-300 (2013)
DOI:10.1007/s12079-013-0197-3

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