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Entry
N00348                      Network                                

Name
HPV E6 to p300-p21-Cell cycle G1/S
Definition
hpvE6 -| EP300 -> TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
  Expanded
K21807 -| 2033 -> 7157 => 1026 -| (595,894,896+1019,1021) -> 5925 // (1869,1870,1871)
Class
nt06130 Cell cycle (virus)
nt06166 Human papillomavirus (HPV)
Type
Virus
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
2033  EP300; E1A binding protein p300
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Perturbant
K21807  E6; HPV protein E6
Reference
  Authors
Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
  Journal
Nat Rev Cancer 10:550-60 (2010)
DOI:10.1038/nrc2886
Reference
  Authors
Patel D, Huang SM, Baglia LA, McCance DJ
  Title
The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.
  Journal
EMBO J 18:5061-72 (1999)
DOI:10.1093/emboj/18.18.5061
Reference
  Authors
Tungteakkhun SS, Duerksen-Hughes PJ
  Title
Cellular binding partners of the human papillomavirus E6 protein.
  Journal
Arch Virol 153:397-408 (2008)
DOI:10.1007/s00705-007-0022-5

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