KEGG   NETWORK: N00350
Entry
N00350                      Network                                

Name
HPV E6 to extrinsic apoptotic pathway
Definition
E6 -| TNFRSF1A
  Expanded
K21807 -| 7132
Class
nt06131 Apoptosis (viruses and bacteria)
nt06150 Cytokine-cytokine receptor interaction (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
hsa04061  Viral protein interaction with cytokine and cytokine receptor
Disease
H00030  Cervical cancer
Gene
7132  TNFRSF1A; TNF receptor superfamily member 1A
Perturbant
K21807 (E6)  E6; HPV protein E6
Reference
  Authors
Jayshree RS, Sreenivas A, Tessy M, Krishna S
  Title
Cell intrinsic & extrinsic factors in cervical carcinogenesis.
  Journal
Indian J Med Res 130:286-95 (2009)
Reference
  Authors
Garnett TO, Duerksen-Hughes PJ
  Title
Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
  Journal
Arch Virol 151:2321-35 (2006)
DOI:10.1007/s00705-006-0821-0
Reference
  Authors
Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
  Title
The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
  Journal
J Biol Chem 277:21730-9 (2002)
DOI:10.1074/jbc.M200113200

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