KEGG   NETWORK: N00356
Entry
N00356                      Network                                

Name
HPV E7 to PP2A-AKT signaling patyway
Definition
E7 -| PP2A
  Expanded
K21809 -| ((5515,5516)+(5518,5519)+(5520,5521,5522,55844,5523,28227,55012,5525,5526,5527,5528,5529))
Class
nt06114 PI3K signaling (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
5515  PPP2CA; protein phosphatase 2 catalytic subunit alpha
5516  PPP2CB; protein phosphatase 2 catalytic subunit beta
5518  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha
5519  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta
5520  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha
5521  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta
5522  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma
55844  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta
5523  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha
28227  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta
55012  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma
5525  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha
5526  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta
5527  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma
5528  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta
5529  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon
Perturbant
K21809 (E7)  E7; HPV protein E7
Reference
  Authors
Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
  Title
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
  Journal
Mol Cancer 14:87 (2015)
DOI:10.1186/s12943-015-0361-x
Reference
  Authors
Pim D, Massimi P, Dilworth SM, Banks L
  Title
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A.
  Journal
Oncogene 24:7830-8 (2005)
DOI:10.1038/sj.onc.1208935

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