KEGG   NETWORK: N00357Help
Entry
N00357                      Network                                

Name
HPV E6 to MTOR signaling pathway
Definition
(hpvE6+UBE3A) -| (TSC1+TSC2) -| RHEB -> MTOR -> S6K
  Expanded
(K21807+7337) -| (7248+7249) -| 6009 -> 2475 -> (6198,6199)
Class
nt06114 PI3K signaling (viruses)
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
7337  UBE3A; ubiquitin protein ligase E3A
7248  TSC1; TSC complex subunit 1
7249  TSC2; TSC complex subunit 2
6009  RHEB; Ras homolog, mTORC1 binding
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Perturbant
K21807  E6; HPV protein E6
Reference
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
  Authors
Zheng L, Ding H, Lu Z, Li Y, Pan Y, Ning T, Ke Y
  Title
E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6.
  Journal
Genes Cells 13:285-94 (2008)
DOI:10.1111/j.1365-2443.2008.01162.x

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