KEGG   NETWORK: N00375Help
Entry
N00375                      Network                                

Name
HPV E7 to TNF-IRF1 signaling pathway
Definition
(hpvE7+HDAC+CHD4) -| IRF1 => IFNB1
  Expanded
(K21809+(3065,3066)+1108) -| 3659 => 3456
Class
nt06123 TNF signaling (virus)
nt06166 Human papillomavirus (HPV)
Type
Virus
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
3065  HDAC1; histone deacetylase 1
3066  HDAC2; histone deacetylase 2
1108  CHD4; chromodomain helicase DNA binding protein 4
3659  IRF1; interferon regulatory factor 1
3456  IFNB1; interferon beta 1
Perturbant
K21809  E7; HPV protein E7
Reference
  Authors
Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
  Title
Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
  Journal
J Biol Chem 275:6764-9 (2000)
DOI:10.1074/jbc.275.10.6764
Reference
  Authors
Koromilas AE, Li S, Matlashewski G
  Title
Control of interferon signaling in human papillomavirus infection.
  Journal
Cytokine Growth Factor Rev 12:157-70 (2001)
DOI:10.1016/S1359-6101(00)00023-X
Reference
  Authors
Yim EK, Park JS
  Title
The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.
  Journal
Cancer Res Treat 37:319-24 (2005)
DOI:10.4143/crt.2005.37.6.319

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