KEGG   NETWORK: N00385Help
Entry
N00385                      Network                                

Name
HCMV gB to PDGFR-PI3K signaling pathway
Definition
hcmvUL55 -> PDGFRB -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
K22773 -> 5159 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06114 PI3K signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
5159  PDGFRB; platelet derived growth factor receptor beta
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Perturbant
K22773  gB; envelope glycoprotein B
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Price P (ed).
  Title
Manifestations of Cytomegalovirus Infection
  Journal
IntechOpen (2013)
DOI:10.5772/50832
Reference
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725

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