KEGG   NETWORK: N00387Help
Entry
N00387                      Network                                

Name
HCMV IE1-72/IE2-86 to PI3K signaling pathway
Definition
(hcmvIE1-72,hcmvIE2-86) -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
(K22774,K22775) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06114 PI3K signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Perturbant
K22774  UL123; immediate-early protein 1
K22775  UL122; viral transcription factor IE2
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Price P (ed).
  Title
Manifestations of Cytomegalovirus Infection
  Journal
IntechOpen (2013)
DOI:10.5772/50832
Reference
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
  Authors
Cobbs CS, Soroceanu L, Denham S, Zhang W, Kraus MH
  Title
Modulation of oncogenic phenotype in human glioma cells by cytomegalovirus IE1-mediated mitogenicity.
  Journal
Cancer Res 68:724-30 (2008)
DOI:10.1158/0008-5472.CAN-07-2291
Reference
  Authors
Yu Y, Alwine JC
  Title
Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.
  Journal
J Virol 76:3731-8 (2002)
DOI:10.1128/JVI.76.8.3731-3738.2002

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