KEGG   NETWORK: N00406Help
Entry
N00406                      Network                                

Name
HCMV US28 to GNA12/13-Rho signaling pathway
Definition
(CCL2,CCL3,CCL4,CCL5,CX3CL1) -> hcmvUS28 -> GNA12/13 -> (ARHGEF12,ARHGEF1) -> RHOA -> ROCK1/2 -> CTNNB1
  Expanded
(6347,6348,6351,6352,6376) -> K22781 -> (2768,10672) -> (23365,9138) -> 387 -> (6093,9475) -> 1499
Class
nt06124 Chemokine signaling (virus)
nt06167 Human cytomegalovirus (HCMV)
Type
Virus
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
6347  CCL2; C-C motif chemokine ligand 2
6348  CCL3; C-C motif chemokine ligand 3
6351  CCL4; C-C motif chemokine ligand 4
6352  CCL5; C-C motif chemokine ligand 5
6376  CX3CL1; C-X3-C motif chemokine ligand 1
2768  GNA12; G protein subunit alpha 12
10672  GNA13; G protein subunit alpha 13
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12
9138  ARHGEF1; Rho guanine nucleotide exchange factor 1
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
1499  CTNNB1; catenin beta 1
Perturbant
K22781  US28; envelope protein US28
Reference
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935

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