KEGG   NETWORK: N00431Help
Entry
N00431                      Network                                

Name
HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway
Definition
hivEnv -> (CXCR4,CCR5) -> GNAI -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
K19287 -> (7852,1234) -> (2770,2771,2773) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06124 Chemokine signaling (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
7852  CXCR4; C-X-C motif chemokine receptor 4
1234  CCR5; C-C motif chemokine receptor 5 (gene/pseudogene)
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Perturbant
K19287  gp160; envelope glycoprotein gp160
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c

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