KEGG   NETWORK: N00442
Entry
N00442                      Network                                

Name
HIV Nef to TNF-NFKB signaling pathway
Definition
Nef -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB
  Expanded
K22891 -> (8737+8717+(7186,7188)) -> ((10454,23118,257397)+6885) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06123 TNF signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
8737  RIPK1; receptor interacting serine/threonine kinase 1
8717  TRADD; TNFRSF1A associated via death domain
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397  TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K22891 (Nef)  nef; HIV-1 protein Nef
Reference
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
  Authors
Khan KA, Abbas W, Varin A, Kumar A, Di Martino V, Dichamp I, Herbein G
  Title
HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages.
  Journal
J Innate Immun 5:639-56 (2013)
DOI:10.1159/000350517

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