KEGG   NETWORK: N00451Help
Entry
N00451                      Network                                

Name
HIV Tat to intrinsic apoptotic pathway
Definition
hivTat -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
K19258 -| (596,598) -| (581,578) -> 54205 -- 317 -> 842 -> (836,840)
Class
nt06131 Apoptosis (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
596  BCL2; BCL2, apoptosis regulator
598  BCL2L1; BCL2 like 1
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Perturbant
K19258  tat; protein Tat
Reference
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
DOI:10.2174/1874357920130621001
Reference
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
Reference
  Authors
Fevrier M, Dorgham K, Rebollo A
  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
  Journal
Viruses 3:586-612 (2011)
DOI:10.3390/v3050586

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