KEGG   NETWORK: N00474Help
Entry
N00474                      Network                                

Name
EBV BHRF1 to intrinsic apoptotic pathway
Definition
ebvBHRF1 -| BCL2L11 -| BCL2 -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K19463 -| 10018 -| 596 -| (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
10018  BCL2L11; BCL2 like 11
596  BCL2; BCL2, apoptosis regulator
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K19463  BHRF1; apoptosis regulator BHRF1
Reference
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
  Authors
Kvansakul M, Wei AH, Fletcher JI, Willis SN, Chen L, Roberts AW, Huang DC, Colman PM
  Title
Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
  Journal
PLoS Pathog 6:e1001236 (2010)
DOI:10.1371/journal.ppat.1001236
Reference
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189

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