KEGG   NETWORK: N00478Help
Entry
N00478                      Network                                

Name
EBV BARF1 to intrinsic apoptotic pathway
Definition
ebvBARF1 -> BCL2 -| (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K22973 -> 596 -| (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses)
nt06165 Epstein-Barr virus (EBV)
Type
Pathogen
Pathway
hsa05169  Epstein-Barr virus infection
Disease
H00008  Burkitt lymphoma
H00007  Hodgkin lymphoma
H00054  Nasopharyngeal cancer
Gene
596  BCL2; BCL2, apoptosis regulator
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K22973  BARF1; HHV4 secreted protein BARF1
Reference
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
  Authors
Sheng W, Decaussin G, Sumner S, Ooka T
  Title
N-terminal domain of BARF1 gene encoded by Epstein-Barr virus is essential for malignant transformation of rodent fibroblasts and activation of BCL-2.
  Journal
Oncogene 20:1176-85 (2001)
DOI:10.1038/sj.onc.1204217
Reference
  Authors
Sheng W, Decaussin G, Ligout A, Takada K, Ooka T
  Title
Malignant transformation of Epstein-Barr virus-negative Akata cells by introduction of the BARF1 gene carried by Epstein-Barr virus.
  Journal
J Virol 77:3859-65 (2003)
DOI:10.1128/JVI.77.6.3859-3865.2003

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