KEGG   NETWORK: N00501Help
Entry
N00501                      Network                                

Name
HTLV-1 Tax to EGFR-PI3K-NFKB signaling pathway
Definition
htlvTAX -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
  Expanded
K21857 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06214 PI3K signaling
nt06114 PI3K signaling (viruses)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K21857  tax; protein Tax-1
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111

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