KEGG   NETWORK: N00502Help
Entry
N00502                      Network                                

Name
HTLV-1 Tax to PTEN-PIP3-AKT signaling pathway
Definition
htlvTAX -| DLG1 -> PTEN -| PIP3 -> AKT
  Expanded
K21857 -| 1739 -> 5728 -| C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
nt06114 PI3K signaling (viruses)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
1739  DLG1; discs large MAGUK scaffold protein 1
5728  PTEN; phosphatase and tensin homolog
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
K21857  tax; protein Tax-1
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:E8 (2016)
DOI:10.3390/pathogens5010008
Reference
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746

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