KEGG   NETWORK: N00505
Entry
N00505                      Network                                

Name
CD40-NFKB signaling pathway
Definition
CD40LG -> CD40 -> (TRAF2+TRAF3) -> NIK -> IKKA -> (NFKB2+RELB)
  Expanded
959 -> 958 -> (7186+7187) -> 9020 -> 1147 -> (4791+5971)
Class
nt06223 TNF signaling
nt06123 TNF signaling (viruses and bacteria)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Reference
Pathway
hsa04064  NF-kappa B signaling pathway
Gene
959  CD40LG; CD40 ligand
958  CD40; CD40 molecule
7186  TRAF2; TNF receptor associated factor 2
7187  TRAF3; TNF receptor associated factor 3
9020  MAP3K14; mitogen-activated protein kinase kinase kinase 14
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
4791  NFKB2; nuclear factor kappa B subunit 2
5971  RELB; RELB proto-oncogene, NF-kB subunit
Reference
  Authors
Hayden MS, Ghosh S
  Title
Regulation of NF-kappaB by TNF family cytokines.
  Journal
Semin Immunol 26:253-66 (2014)
DOI:10.1016/j.smim.2014.05.004
Reference
  Authors
Hobeika E, Nielsen PJ, Medgyesi D
  Title
Signaling mechanisms regulating B-lymphocyte activation and tolerance.
  Journal
J Mol Med (Berl) 93:143-58 (2015)
DOI:10.1007/s00109-015-1252-8
Reference
  Authors
Elgueta R, Benson MJ, de Vries VC, Wasiuk A, Guo Y, Noelle RJ
  Title
Molecular mechanism and function of CD40/CD40L engagement in the immune system.
  Journal
Immunol Rev 229:152-72 (2009)
DOI:10.1111/j.1600-065X.2009.00782.x
Reference
  Authors
Bonizzi G, Karin M
  Title
The two NF-kappaB activation pathways and their role in innate and adaptive immunity.
  Journal
Trends Immunol 25:280-8 (2004)
DOI:10.1016/j.it.2004.03.008

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