KEGG   NETWORK: N00513Help
Entry
N00513                      Network                                

Name
Mutation-activated EGFR to RAS-ERK signaling pathway
Definition
EGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
  Expanded
1956v5 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Variant
1956v5  EGFR mutation in glioblastoma
Reference
  Authors
Xu H, Zong H, Ma C, Ming X, Shang M, Li K, He X, Du H, Cao L
  Title
Epidermal growth factor receptor in glioblastoma.
  Journal
Oncol Lett 14:512-516 (2017)
DOI:10.3892/ol.2017.6221
Reference
  Authors
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA
  Title
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
  Journal
Oncogene 37:1561-1575 (2018)
DOI:10.1038/s41388-017-0045-7

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