KEGG   NETWORK: N00514Help
Entry
N00514                      Network                                

Name
Mutation-activated EGFR to PI3K signaling pathway
Definition
EGFR* -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
1956v5 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
1956v5  EGFR mutation in glioblastoma
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Hatanpaa KJ, Burma S, Zhao D, Habib AA
  Title
Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance.
  Journal
Neoplasia 12:675-84 (2010)
DOI:10.1593/neo.10688
Reference
  Authors
Xu H, Zong H, Ma C, Ming X, Shang M, Li K, He X, Du H, Cao L
  Title
Epidermal growth factor receptor in glioblastoma.
  Journal
Oncol Lett 14:512-516 (2017)
DOI:10.3892/ol.2017.6221
Reference
  Authors
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA
  Title
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
  Journal
Oncogene 37:1561-1575 (2018)
DOI:10.1038/s41388-017-0045-7

DBGET integrated database retrieval system