KEGG   NETWORK: N00514
Entry
N00514                      Network                                
Name
Mutation-activated EGFR to PI3K signaling pathway
Definition
EGFR* -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
1956v5 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06273 Glioma
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
1956  EGFR; epidermal growth factor receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
1956v5 (EGFR*)  EGFR mutation in glioblastoma
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20824044
  Authors
Hatanpaa KJ, Burma S, Zhao D, Habib AA
  Title
Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance.
  Journal
Neoplasia 12:675-84 (2010)
DOI:10.1593/neo.10688
Reference
PMID:28693199
  Authors
Xu H, Zong H, Ma C, Ming X, Shang M, Li K, He X, Du H, Cao L
  Title
Epidermal growth factor receptor in glioblastoma.
  Journal
Oncol Lett 14:512-516 (2017)
DOI:10.3892/ol.2017.6221
Reference
PMID:29321659
  Authors
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA
  Title
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies.
  Journal
Oncogene 37:1561-1575 (2018)
DOI:10.1038/s41388-017-0045-7

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Network (1)   
   KEGG VARIANT (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (8)   
   KEGG GENES (8)   
Literature (3)   
   PubMed (3)   
All databases (14)   

Download RDF
DBGET integrated database retrieval system