KEGG   NETWORK: N00525
Entry
N00525                      Network                                

Name
HCV NS5A to TNF-NFKB signaling pathway
Definition
NS5A -| (TRADD+TRAF2)
  Expanded
K22275 -| (8717+7186)
Class
nt06263 Hepatocellular carcinoma
nt06123 TNF signaling (viruses and bacteria)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
8717  TRADD; TNFRSF1A associated via death domain
7186  TRAF2; TNF receptor associated factor 2
Perturbant
K22275 (NS5A)  NS5A; HCV non-structural protein 5A
Reference
  Authors
Park KJ, Choi SH, Lee SY, Hwang SB, Lai MM
  Title
Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation.
  Journal
J Biol Chem 277:13122-8 (2002)
DOI:10.1074/jbc.M111599200
Reference
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309

DBGET integrated database retrieval system