KEGG   NETWORK: N00527Help
Entry
N00527                      Network                                

Name
HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
hcvCore -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
K22271 -> 355 -> 8772 -> 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06263 Hepatocellular carcinoma
nt06131 Apoptosis (viruses)
nt06163 Hepatitis C virus (HCV)
Type
Pathogen
Pathway
hsa05160  Hepatitis C
Disease
H00048  Hepatocellular carcinoma
Gene
355  FAS; Fas cell surface death receptor
8772  FADD; Fas associated via death domain
841  CASP8; caspase 8
637  BID; BH3 interacting domain death agonist
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K22271  Core; HCV core protein
Reference
  Authors
Ruggieri A, Murdolo M, Rapicetta M
  Title
Induction of FAS ligand expression in a human hepatoblastoma cell line by HCV core protein.
  Journal
Virus Res 97:103-10 (2003)
DOI:10.1016/j.virusres.2003.08.004
Reference
  Authors
Tran G.
  Title
The role of hepatitis C virus in the pathogenesis of hepatocellular carcinoma
  Journal
Bioscience Horizons 1(2):167-175 (2008)
Reference
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865

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