KEGG   NETWORK: N00541Help
Entry
N00541                      Network                                

Name
HBV HBx to RAS-ERK signaling pathway
Definition
hbvX -> RAS -> RAF1 -> MEK -> ERK
  Expanded
K21854 -> (3265,3845,4893) -> 5894 -> (5604,5605) -> (5594,5595)
Class
nt06110 MAPK signaling (virus)
nt06162 Hepatitis B virus (HBV)
Type
Virus
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Perturbant
K21854  X; HBV protein X
Reference
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:7937954
  Authors
Benn J, Schneider RJ
  Title
Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.
  Journal
Proc Natl Acad Sci U S A 91:10350-4 (1994)
DOI:10.1073/pnas.91.22.10350

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