KEGG   NETWORK: N00546Help
Entry
N00546                      Network                                

Name
CXCL12-CXCR4-PKC-ERK signaling pathaway
Definition
CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> PKC -> RAF -> MEK -> ERK
  Expanded
6387 -> 7852 -> 2776 -> (23236,5330,5331,5332,5335,5336) -> C01245 -> C00076 -> (5578,5579,5582) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06124 Chemokine signaling (virus)
nt06162 Hepatitis B virus (HBV)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
6387  CXCL12; C-X-C motif chemokine ligand 12
7852  CXCR4; C-X-C motif chemokine receptor 4
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Werry TD, Sexton PM, Christopoulos A
  Title
"Ins and outs" of seven-transmembrane receptor signalling to ERK.
  Journal
Trends Endocrinol Metab 16:26-33 (2005)
DOI:10.1016/j.tem.2004.11.008
Reference
  Authors
Cojoc M, Peitzsch C, Trautmann F, Polishchuk L, Telegeev GD, Dubrovska A
  Title
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis.
  Journal
Onco Targets Ther 6:1347-61 (2013)
DOI:10.2147/OTT.S36109

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