KEGG   NETWORK: N00562
Entry
N00562                      Network                                

Name
HSV US3 to TLR2/4-NFKB signaling pathway
Definition
US3 -| (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB
  Expanded
K19439 -| (7189+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970)
Class
nt06121 TLR signaling (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
7189  TRAF6; TNF receptor associated factor 6
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; conserved helix-loop-helix ubiquitous kinase
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
Perturbant
K19439 (US3)  US3; Simplexvirus serine/threonine-protein kinase US3
Reference
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
  Authors
Sen J, Liu X, Roller R, Knipe DM
  Title
Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination.
  Journal
Virology 439:65-73 (2013)
DOI:10.1016/j.virol.2013.01.026

DBGET integrated database retrieval system