KEGG   NETWORK: N00585
Entry
N00585                      Network                                

Name
HSV US3 to intrinsic apoptotic pathway
Definition
US3 -| BAD
  Expanded
K19439 -| 572
Class
nt06131 Apoptosis (viruses and bacteria)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
572  BAD; BCL2 associated agonist of cell death
Perturbant
K19439 (US3)  US3; Simplexvirus serine/threonine-protein kinase US3
Reference
  Authors
Ogg PD, McDonell PJ, Ryckman BJ, Knudson CM, Roller RJ
  Title
The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members.
  Journal
Virology 319:212-24 (2004)
DOI:10.1016/j.virol.2003.10.019
Reference
  Authors
Cartier A, Komai T, Masucci MG
  Title
The Us3 protein kinase of herpes simplex virus 1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad.
  Journal
Exp Cell Res 291:242-50 (2003)
DOI:10.1016/s0014-4827(03)00375-6
Reference
  Authors
Diehl N, Schaal H
  Title
Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway.
  Journal
Viruses 5:3192-212 (2013)
DOI:10.3390/v5123192

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