KEGG   NETWORK: N00684Help
Entry
N00684                      Network                                

Name
MV F/H to CD28-PI3K signaling pathway
Definition
(mvF,mvH) -> CBLB -| PI3K -> PIP3 -> AKT
  Expanded
(K19379,K19378) -> 868 -| (5290,5291,5293) -> C05981 -> (207,208,10000)
Class
nt06114 PI3K signaling (viruses)
nt06169 Measles virus (MV)
Type
Pathogen
Pathway
hsa05162  Measles
Disease
H00394  Measles
Gene
868  CBLB; Cbl proto-oncogene B
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Perturbant
K19379  F; Morbillivirus fusion glycoprotein F0
K19378  H; Morbillivirus hemagglutinin glycoprotein
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102

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