KEGG   NETWORK: N00690
Entry
N00690                      Network                                

Name
TLR7/9-IRF7 signaling pathway
Definition
(TLR7,TLR9) -> MYD88 -> (IRAK4+IRAK1) -> IRF7 => (IFNA,IFNB1)
  Expanded
(51284,54106) -> 4615 -> (51135+3654) -> 3665 => ((3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452),3456)
Class
nt06121 TLR signaling (viruses and bacteria)
nt06169 Measles virus (MV)
Type
Reference
Pathway
hsa04620  Toll-like receptor signaling pathway
Gene
51284  TLR7; toll like receptor 7
54106  TLR9; toll like receptor 9
4615  MYD88; MYD88, innate immune signal transduction adaptor
51135  IRAK4; interleukin 1 receptor associated kinase 4
3654  IRAK1; interleukin 1 receptor associated kinase 1
3665  IRF7; interferon regulatory factor 7
3439  IFNA1; interferon alpha 1
3440  IFNA2; interferon alpha 2
3441  IFNA4; interferon alpha 4
3442  IFNA5; interferon alpha 5
3443  IFNA6; interferon alpha 6
3444  IFNA7; interferon alpha 7
3445  IFNA8; interferon alpha 8
3446  IFNA10; interferon alpha 10
3447  IFNA13; interferon alpha 13
3448  IFNA14; interferon alpha 14
3449  IFNA16; interferon alpha 16
3451  IFNA17; interferon alpha 17
3452  IFNA21; interferon alpha 21
3456  IFNB1; interferon beta 1
Reference
  Authors
Zhu J, Mohan C
  Title
Toll-like receptor signaling pathways--therapeutic opportunities.
  Journal
Mediators Inflamm 2010:781235 (2010)
DOI:10.1155/2010/781235
Reference
  Authors
O'Neill LA, Golenbock D, Bowie AG
  Title
The history of Toll-like receptors - redefining innate immunity.
  Journal
Nat Rev Immunol 13:453-60 (2013)
DOI:10.1038/nri3446
Reference
  Authors
Blasius AL, Beutler B
  Title
Intracellular toll-like receptors.
  Journal
Immunity 32:305-15 (2010)
DOI:10.1016/j.immuni.2010.03.012

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