KEGG   NETWORK: N00732
Entry
N00732                      Network                                

Name
IAV PB1-F2/PB2 to RIG-I-like receptor signaling pathway
Definition
(PB1F2,PB2) -| MAVS
  Expanded
(K19397,K19388) -| 57506
Class
nt06133 RLR signaling (viruses)
nt06170 Influenza A virus (IAV)
Type
Pathogen
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
57506  MAVS; mitochondrial antiviral signaling protein
Perturbant
K19397 (PB1F2)  PB1F2; Influenza A virus protein PB1-F2
K19388 (PB2)  PB2; Influenza A virus polymerase basic protein 2
Reference
  Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
  Title
Evasion of influenza A viruses from innate and adaptive immune responses.
  Journal
Viruses 4:1438-76 (2012)
DOI:10.3390/v4091438
Reference
  Authors
Varga ZT, Ramos I, Hai R, Schmolke M, Garcia-Sastre A, Fernandez-Sesma A, Palese P
  Title
The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein.
  Journal
PLoS Pathog 7:e1002067 (2011)
DOI:10.1371/journal.ppat.1002067
Reference
  Authors
Dudek SE, Wixler L, Nordhoff C, Nordmann A, Anhlan D, Wixler V, Ludwig S
  Title
The influenza virus PB1-F2 protein has interferon antagonistic activity.
  Journal
Biol Chem 392:1135-44 (2011)
DOI:10.1515/BC.2011.174
Reference
  Authors
Graef KM, Vreede FT, Lau YF, McCall AW, Carr SM, Subbarao K, Fodor E
  Title
The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon.
  Journal
J Virol 84:8433-45 (2010)
DOI:10.1128/JVI.00879-10

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