KEGG   NETWORK: N00742Help
Entry
N00742                      Network                                

Name
NLRP3 Inflammasome signaling pathway
Definition
(NLRP3+PYCARD) -> CASP1 -> (IL1B,IL18,IL33)
  Expanded
(114548+29108) -> 834 -> (3553,3606,90865)
Class
nt06139 NLR signaling (viruses and bacteria)
nt06170 Influenza A virus (IAV)
Type
Reference
Pathway
hsa04621  NOD-like receptor signaling pathway
Gene
114548  NLRP3; NLR family pyrin domain containing 3
29108  PYCARD; PYD and CARD domain containing
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
3606  IL18; interleukin 18
90865  IL33; interleukin 33
Reference
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
  Authors
Coll RC, O'Neill L, Schroder K
  Title
Questions and controversies in innate immune research: what is the physiological role of NLRP3?
  Journal
Cell Death Discov 2:16019 (2016)
DOI:10.1038/cddiscovery.2016.19

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