KEGG   NETWORK: N00744Help
Entry
N00744                      Network                                

Name
IAV HA to ERK signaling pathway
Definition
iavHA -> PRKCA -> RAF -> MEK -> ERK
  Expanded
K19251 -> 5578 -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06110 MAPK signaling (virus)
nt06170 Influenza A virus (IAV)
Type
Virus
Pathway
hsa05164  Influenza A
Disease
H00398  Influenza
Gene
5578  PRKCA; protein kinase C alpha
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Perturbant
K19251  HA; hemagglutinin
Reference
  Authors
Dai X, Zhang L, Hong T
  Title
Host cellular signaling induced by influenza virus.
  Journal
Sci China Life Sci 54:68-74 (2011)
DOI:10.1007/s11427-010-4116-z
Reference
  Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
  Title
Interplay between influenza A virus and the innate immune signaling.
  Journal
Microbes Infect 12:81-7 (2010)
DOI:10.1016/j.micinf.2009.09.007
Reference
  Authors
Marjuki H, Alam MI, Ehrhardt C, Wagner R, Planz O, Klenk HD, Ludwig S, Pleschka S
  Title
Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling.
  Journal
J Biol Chem 281:16707-15 (2006)
DOI:10.1074/jbc.M510233200
Reference
  Authors
Marjuki H, Yen HL, Franks J, Webster RG, Pleschka S, Hoffmann E
  Title
Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.
  Journal
Virol J 4:134 (2007)
DOI:10.1186/1743-422X-4-134

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