KEGG   NETWORK: N00859
Entry
N00859                      Network                                

Name
Yersinia YopP/J to TLR2/4-NFKB signaling pathway
Definition
YopP/J -| (TRAF6+TRAF2+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6)
  Expanded
K08598 -| (7189+7186+6885+23118) -> (1147+3551+8517) -> 4792 -> (4790+5970) => (7124,3569)
Class
nt06121 TLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05135  Yersinia infection
Disease
H00297  Plague
H00298  Yersiniosis
Gene
7189  TRAF6; TNF receptor associated factor 6
7186  TRAF2; TNF receptor associated factor 2
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
1147  CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517  IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792  NFKBIA; NFKB inhibitor alpha
4790  NFKB1; nuclear factor kappa B subunit 1
5970  RELA; RELA proto-oncogene, NF-kB subunit
7124  TNF; tumor necrosis factor
3569  IL6; interleukin 6
Perturbant
K08598 (YopP/J)  yopJ; YopJ protease family
Reference
  Authors
Haase R, Richter K, Pfaffinger G, Courtois G, Ruckdeschel K
  Title
Yersinia outer protein P suppresses TGF-beta-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells.
  Journal
J Immunol 175:8209-17 (2005)
DOI:10.4049/jimmunol.175.12.8209
Reference
  Authors
Zhou H, Monack DM, Kayagaki N, Wertz I, Yin J, Wolf B, Dixit VM
  Title
Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation.
  Journal
J Exp Med 202:1327-32 (2005)
DOI:10.1084/jem.20051194

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