KEGG   NETWORK: N00862Help
Entry
N00862                      Network                                

Name
Yersinia YopP/J to TLR2/4-MAPK signaling pathway
Definition
bYopP/J -| (MEK,MKK3/6,MKK4/7) -> (ERK,p38,JNK) -> AP1 => (IL6,IL8,TNF)
  Expanded
K08598 -| (5604,5605,5606,5608,6416,5609) -> (5594,5595,1432,5600,5603,6300,5599,5601,5602) -> (2353,3725) => (3569,3576,7124)
Class
nt06121 TLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05135  Yersinia infection
Disease
H00297  Plague
H00298  Yersiniosis
Gene
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5606  MAP2K3; mitogen-activated protein kinase kinase 3
5608  MAP2K6; mitogen-activated protein kinase kinase 6
6416  MAP2K4; mitogen-activated protein kinase kinase 4
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
1432  MAPK14; mitogen-activated protein kinase 14
5600  MAPK11; mitogen-activated protein kinase 11
5603  MAPK13; mitogen-activated protein kinase 13
6300  MAPK12; mitogen-activated protein kinase 12
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
3725  JUN; Jun proto-oncogene, AP-1 transcription factor subunit
3569  IL6; interleukin 6
3576  CXCL8; C-X-C motif chemokine ligand 8
7124  TNF; tumor necrosis factor
Perturbant
K08598  yopJ; YopJ protease family
Reference
  Authors
Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC
  Title
A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.
  Journal
Cell Host Microbe 18:682-93 (2015)
DOI:10.1016/j.chom.2015.11.006
Reference
  Authors
Mukherjee S, Keitany G, Li Y, Wang Y, Ball HL, Goldsmith EJ, Orth K
  Title
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.
  Journal
Science 312:1211-4 (2006)
DOI:10.1126/science.1126867
Reference
  Authors
Orth K, Palmer LE, Bao ZQ, Stewart S, Rudolph AE, Bliska JB, Dixon JE
  Title
Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector.
  Journal
Science 285:1920-3 (1999)
DOI:10.1126/science.285.5435.1920

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