KEGG   NETWORK: N00881Help
Entry
N00881                      Network                                

Name
Mutation-inactivated PROKR2 to PROK-PRKR-Gi-ERK signaling pathway
Definition
PROK1/2 -> PROKR2* -> GNAI -> ERK
  Expanded
(84432,60675) -> 128674v1 -> (2770,2771,2773) -> (5594,5595)
Type
Variant
Disease
H00255  Hypogonadotropic hypogonadism
Gene
84432  PROK1; prokineticin 1
60675  PROK2; prokineticin 2
2770  GNAI1; G protein subunit alpha i1
2771  GNAI2; G protein subunit alpha i2
2773  GNAI3; G protein subunit alpha i3
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
128674v1  PROKR2 mutations
Reference
  Authors
Abreu AP, Kaiser UB, Latronico AC
  Title
The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism.
  Journal
Neuroendocrinology 91:283-90 (2010)
DOI:10.1159/000308880
Reference
  Authors
Dode C, Rondard P
  Title
PROK2/PROKR2 Signaling and Kallmann Syndrome.
  Journal
Front Endocrinol (Lausanne) 4:19 (2013)
DOI:10.3389/fendo.2013.00019
Reference
  Authors
Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF Jr, Zhou QY, Pitteloud N
  Title
Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.
  Journal
J Clin Endocrinol Metab 93:3551-9 (2008)
DOI:10.1210/jc.2007-2654
Reference
  Authors
Chen J, Kuei C, Sutton S, Wilson S, Yu J, Kamme F, Mazur C, Lovenberg T, Liu C
  Title
Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
  Journal
Mol Pharmacol 67:2070-6 (2005)
DOI:10.1124/mol.105.011619

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