KEGG   NETWORK: N00921
Entry
N00921                      Network                                

Name
Mutation-inactivated PRLR to PRL-JAK-STAT signaling pathway
Definition
PRL // PRLR* // JAK2 -> STAT5
  Expanded
5617 // 5618v1 // 3717 -> (6776,6777)
Class
nt06325 PRL signaling
Type
Variant
Pathway
hsa04917  Prolactin signaling pathway
Disease
H01388  Hyperprolactinemia
Gene
5617  PRL; prolactin
5618  PRLR; prolactin receptor
3717  JAK2; Janus kinase 2
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
Variant
5618v1  PRLR mutation
Reference
  Authors
Newey PJ, Gorvin CM, Cleland SJ, Willberg CB, Bridge M, Azharuddin M, Drummond RS, van der Merwe PA, Klenerman P, Bountra C, Thakker RV
  Title
Mutant prolactin receptor and familial hyperprolactinemia.
  Journal
N Engl J Med 369:2012-20 (2013)
DOI:10.1056/NEJMoa1307557
Reference
  Authors
Schuff KG, Hentges ST, Kelly MA, Binart N, Kelly PA, Iuvone PM, Asa SL, Low MJ
  Title
Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms.
  Journal
J Clin Invest 110:973-81 (2002)
DOI:10.1172/JCI15912

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